Up-regulated fractalkine (FKN) and its receptor CX3CR1 are involved in fructose-induced neuroinflammation: Suppression by curcumin
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- 作者：Min-Xuan Xu1 ; Rong Yu1 ; Li-Fei Shao ; Yan-Xiu Zhang ; Chen-Xu Ge ; Xin-Meng Liu ; Wen-Yuan Wu ; Jian-Mei Li ; lijm@nju.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Ling-Dong Kong ; kongld@nju.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Fructose ; Neuroinflammation ; Neuronal damage ; FKN/CX3CR1 signaling ; Curcumin
- 刊名：Brain, Behavior, and Immunity
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：58
- 期：Complete
- 页码：69-81
- 全文大小：4113 K
文摘
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Fructose intake stimulated hypothalamic and hippocampal neuroinflammation in mice.
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Fructose feeding caused neuronal damage in the dentate gyrus (DG) of mice.
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FKN/CX3CR1 upregulation was involved in the neuroinflammation in fructose-fed mice.
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Curcumin prevented neuronal damage by inhibiting neuroinflammation in these mice.
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Curcumin suppressed the upregulation of FKN/CX3CR1 in fructose-fed mice.