CX₃CR1 ablation ameliorates motor and respiratory dysfunctions and improves survival of a Rett syndrome mouse model

详细信息    查看全文

• 作者：Makoto Horiuchi^a ; Lucas Smith^a ; Izumi Maezawa^a ; ^b ; Lee-Way Jin^a ; ^b ; ^{lwjin@ucdavis.edu}
• 关键词：Rett syndrome ; MeCP2 ; Microglia ; CX3CR1
• 刊名：Brain, Behavior, and Immunity
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：60
• 期：Complete
• 页码：106-116
• 全文大小：2423 K
• 卷排序：60

文摘

CX3CR1 ablation improves the life span, body weight, and symptomatic scores of Mecp2KO mice. CX3CR1 ablation improves the respiratory parameters of Mecp2KO mice. CX3CR1 ablation improves the motor performance of Mecp2KO mice. CX3CR1 ablation recovers neuronal or microglial morphology of Mecp2KO mice. CX3CR1 ablation increases the expression of insulin-like growth factor 1 in Mecp2KO mice.