文摘
A lymphatic-specific deletion of Cx43 was made using a Lyve-1 Cre allele. Cx43∆LEC mice exhibit insufficient lymph transport, leaky valves, and chylothorax. Cx43∆LEC mice show delayed lymphatic valve initiation and reduced valve frequency. Cx43∆LEC mice display immature valves with incomplete elongation of valve leaflets. Cx43 is required in lymphatic endothelial cells for normal valve development.