Schistosoma antigens rSm29 and rSh-TSP-2 reduce the levels of CXCL9 in supernatants of PBMCs of individuals with HTLV-1. Schistosoma Antigens downregulate the levels of CXCL9 and induced high level of IL-10 in PBMC culture of HTLV-1-infected individuals. Schistosoma antigens are able to supress in vitro the levels os proinflammatory chemokines involved in the pathology of HTLV-1 infection.