Induction of CXCR2 ligands, stem cell-like phenotype, and metastasis in chemotherapy-resistant breast cancer cells
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- 作者：Bhawna Sharmaa ; b ; Michelle L. Varneya ; Sugandha Saxenaa ; Lingyun Wua ; Rakesh K. Singha ; c ; rsingh@unmc.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Chemokines ; Therapy resistance ; CXCR2 ; Stem cell
- 刊名：Cancer Letters
- 出版年：2016
- 出版时间：28 March 2016
- 年：2016
- 卷：372
- 期：2
- 页码：192-200
- 全文大小：2936 K
文摘
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Differential regulation of CXCR2 ligands and stem cell-like and mesenchymal phenotypes depends on chemotherapy used.
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Drug-resistant cell lines formed smaller primary tumors but were highly metastatic.
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Targeting CXCR2 signaling may help circumvent therapy resistance in breast cancer.