PP2A^Cdc55 Phosphatase Imposes Ordered Cell-Cycle Phosphorylation by Opposing Threonine Phosphorylation

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• 作者：Molly Godfrey¹ ; ³ ; Sandra A. Touati¹ ; Meghna Kataria¹ ; Andrew Jones² ; Ambrosius P. Snijders² ; Frank Uhlmann¹ ; ⁴ ; ^{frank.uhlmann@crick.ac.uk}
• 关键词：cell cycle ; cyclin-dependent kinase ; PP2A phosphatase ; Saccharomyces cerevisiae ; phosphoproteome analysis
• 刊名：Molecular Cell
• 出版年：2017
• 出版时间：2 February 2017
• 年：2017
• 卷：65
• 期：3
• 页码：393-402.e3
• 全文大小：1712 K
• 卷排序：65

文摘

The phosphatase PP2ACdc55 counteracts Cdk phosphorylation during the cell cycle It does so specifically on threonine, but not serine, phosphorylation sites Consequently, threonine phosphorylation is a late event in the cell cycle Thereby, PP2ACdc55 contributes to setting the timing of mitosis