Encorafenib (LGX818), a potent BRAF inhibitor, induces senescence accompanied by autophagy in BRAFV600E melanoma cells
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- 作者：Zhen Lia ; 1 ; Ke Jiangb ; 1 ; Xiaofang Zhuc ; Guibin Linb ; Fei Songd ; Yongfu Zhaod ; Yongjun Piaoe ; Jiwei Liuf ; Wei Chengb ; Xiaolin Bib ; Peng Gongf ; gongpengdalian@163.com" class="auth_mail" title="E-mail the corresponding author ; Zhiqi Songe ; szqdalian@163.com" class="auth_mail" title="E-mail the corresponding author ; Songshu Mengb ; ssmeng@dmu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：BRAF ; Encorafenib (LGX818) ; Senescence ; Autophagy ; Melanoma
- 刊名：Cancer Letters
- 出版年：2016
- 出版时间：28 January 2016
- 年：2016
- 卷：370
- 期：2
- 页码：332-344
- 全文大小：5692 K
文摘
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LGX818 exhibits anti-proliferative activity in BRAFV600E melanoma cells.
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GSK3β does not contribute to LGX818-triggered turnover of CyclinD1.
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LGX818 induces senescence rather than apoptosis in BRAFV600E melanoma cells.
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LGX818 triggers autophagy by inhibiting the mTOR pathway in BRAFV600E melanoma cells.
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Autophagy plays a role in LGX818-induced senescence.