Synthesis of functionalized 2,3-dihydropyrroles by oxidative radical cyclization of N-Sulfonyl β-enamino esters with alkenes

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• 作者：Masahiro Yoshida^a ; ^{yoshida@ph.bunri-u.ac.jp" class="auth_mail" title="E-mail the corresponding author} ; Asuka Kobayashi^b ; Atsushi Nakayama^b ; Kosuke Namba^b
• 关键词：Cycloadditions ; Dihydropyrroles ; Heterocycles ; Oxidant ; Radical reactions
• 刊名：Tetrahedron
• 出版年：2016
• 出版时间：19 May 2016
• 年：2016
• 卷：72
• 期：20
• 页码：2544-2551
• 全文大小：1372 K

文摘

Oxidative radical cyclization of N-sulfonyl β-enamino esters with alkenes has been developed. Substituted 2,3-dihydropyrroles were produced when the reactions were carried out in the presence of CAN and Cu(OAc)₂ as the oxidant. Intramolecular cyclization of β-enamino carbonyl compounds having an alkenyl and an alkynyl side chain proceeded to afford the corresponding bicyclic products, respectively.