Two new entries to the ABF tricyclic ring system of 7,17-seco-type C₁₉-diterpenoid alkaloids via free radical cyclization and [3+2] cycloaddition of nitrile oxide

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• 作者：Yong-Li Li^a ; Meng-Chen Liu^a ; Yin-Juan Meng^a ; Liang Xu^a ; ^b ; ^{liangxu@scu.edu.cn" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Diterpenoid alkaloids ; ABF rings ; Radical cyclization ; [3+2] Cycloaddition ; Nitrile oxide
• 刊名：Tetrahedron
• 出版年：2016
• 出版时间：9 June 2016
• 年：2016
• 卷：72
• 期：23
• 页码：3171-3176
• 全文大小：538 K

文摘

Two new approaches for the construction the ABF ring systems of 7,17-seco-type C₁₉-diterpenoid alkaloids have been successfully developed by using free radical cyclization and intramolecular nitrile oxide cycloaddition, respectively, as the key steps. Both methods would probably provide alternative strategies for the elaboration of AEF-rings in the total synthesis of 7,17-seco-type C₁₉-diterpenoid alkaloids based on our previously prepared BCD ring systems.