Novel pyrimidine-2,4-dione-1,2,3-triazole and furo[2,3-d]pyrimidine-2-one-1,2,3-triazole hybrids as potential anti-cancer agents: Synthesis, computational and X-ray analysis and biological evaluation
文摘
Pd/Cu-catalyzed reactions gave furo[2,3-d]pyrimidine-2-one–1,2,3-triazole hybrids. Tandem terminal alkyne dimerization and 5-endo-trig cyclization afforded 24a–37a. Precise reaction mechanisms were elucidated by the DFT computational analysis. Compound 7 did not show mitochondrial toxicity in vitro. 7 in Hep-G2 cells inhibited Wee-1 kinase and abolished sphingolipid signaling.