Clove essential oil-in-cyclodextrin-in-liposomes in the aqueous and lyophilized states: From laboratory to large scale using a membrane contactor
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- 作者：Carine Sebaalya ; b ; Catherine Charcossetb ; Serge Stainmesseb ; Hatem Fessib ; Hé ; lè ; ne Greige-Gergesa ; hgreige@ul.edu.lb" class="auth_mail" title="E-mail the corresponding author ; greigegeorges@yahoo.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Clove essential oil ; Drug in cyclodextrin in liposomes ; Double loading technique ; Eugenol ; Freeze-drying ; Scale-up
- 刊名：Carbohydrate Polymers
- 出版年：2016
- 出版时间：15 March 2016
- 年：2016
- 卷：138
- 期：Complete
- 页码：75-85
- 全文大小：2072 K
文摘
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Preparation of clove essential oil-in-cyclodextrin-in-liposomes (DCL) at laboratory and large scales.
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Freeze-drying of liposomes encapsulating inclusion complex of a volatile hydrophobic compound.
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DCL formulations were stable in aqueous dispersions after 1 month of storage at 4 ̊C and in lyophilized forms.
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DCL formulations maintained the DPPH scavenging activity of free clove essential oil, free eugenol and their inclusion complexes.