The genus Rosa and arthritis: Overview on pharmacological perspectives

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• 作者：Brian Chi Yan Cheng^a ; Xiu-Qiong Fu^a ; Hui Guo^a ; Ting Li^a ; Zheng-Zhi Wu^b ; Kelvin Chan^c ; ^d ; Zhi-Ling Yu^a ; ^{zlyu@hkbu.edu.hk}
• 关键词：CCL ; Chemokine C-C motif ligand ; COX ; Cyclooxygenase ; CRP ; C-reactive protein ; DMARDs ; Disease-modifying antirheumatic drugs ; IFN ; Interferon ; IL ; Interleukin ; iNOS ; Inducible nitric oxide synthases ; LOX ; Lipooxygenase ; MDA ; Malondialdehyde ; NF-κB ; Nuclear factor kappa-B ; NSAIDs ; Non-steroidal anti-inflammatory agents ; OA ; Osteoarthritis ; RA ; Rheumatoid arthritis ; RANTES ; Regulated on activation normal T cell expressed and secreted ; SOD ; Superoxide dismutase ; TNF ; Tumour necrosis factor
• 刊名：Pharmacological Research
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：114
• 期：Complete
• 页码：219-234
• 全文大小：2239 K
• 卷排序：114

文摘

The genus Rosa (roses) has long been used in traditional or folk medicine worldwide for the treatment of various types of arthritis including rheumatoid arthritis and osteoarthritis. The active constituents of Rosa spp., such as flavonoids, triterpenoids, and phytosterols, could act on different targets in the NF-κB signalling pathway, inhibit pro-inflammatory enzymes (e.g. MMPs and COX-2), lower the production of inflammatory cytokines and chemokines (e.g. TNF-α, IL-1β, IL-6, CCL5), and reduce oxidative stress, which in turn suppress inflammatory processes. Preclinical and clinical studies have demonstrated that these species possess analgesic, anti-arthritic, anti-inflammatory, anti-oxidative and bone-preserving activities. This review presents comprehensive overview of the mode and mechanism of action of various extracts, preparations, and active constituents from this genus. The dynamic beneficial effects of the products prepared from this genus in arthritis management are summarized. The Rosa genus is a treasure waiting for further exploration by researchers interested in the development of safe and effective anti-arthritic agents.