The cyclophilin D/Drp1 axis regulates mitochondrial fission contributing to oxidative stress-induced mitochondrial dysfunctions in SH-SY5Y cells

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• 作者：Anqi Xiao^a ; Xueqi Gan^b ; ¹ ; Ruiqi Chen^a ; Yanming Ren^a ; Haiyang Yu^b ; ; Chao You^a ; ^{shionaries@126.com}
• 关键词：Cyclophilin D ; Drp1 ; Mitochondrial fission and fusion ; Oxidative stress ; SH-SY5Y cells
• 刊名：Biochemical and Biophysical Research Communications
• 出版年：2017
• 出版时间：29 January 2017
• 年：2017
• 卷：483
• 期：1
• 页码：765-771
• 全文大小：1553 K
• 卷排序：483

文摘

Demonstrated first time the link between the mPTP to mitochondrial dynamics. The role of Cyclophilin D in the regulation of Drp1-mediated mitochondrial fission. CsA as a potential target for governing oxidative stress related neuropathology.