Stereoselective cyclopropanation of chiral 5-substituted dihydro-2H-piperazines

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• 作者：Gianna Reginato^a ; ^{gianna.reginato@iccom.cnr.it} ; Maria Pia Catalani^b ; Alessandro Mordini^a ; Bernardo Pezzati^a ; ^b ; Andrea Bernardelli^b ; Silvia Davalli^b ; Nicola Pace^b
• 刊名：Tetrahedron: Asymmetry
• 出版年：2013
• 出版时间：15 January, 2013
• 年：2013
• 卷：24
• 期：1
• 页码：75-79
• 全文大小：887 K

文摘

The Simmon-Smith cyclopropanation of enantiomerically enriched dehydropiperazines is reported. The reaction is highly stereoselective and allowed us to prepare new, enantiomerically enriched 3-substituted 2,5-diazabicyclo[4.1.0]heptane cores with high diastereomeric purity and a relative anti-configuration, which was assigned by NMR analysis.