Highly diastereoselective synthesis of spiro[cyclopropane-1,3鈥?indolin]-2鈥?ones via catalyst-free cyclopropanation using ethyl diazoacetate

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• 作者：Ram Awatar Maurya^a ; ^{ramaurya@iict.res.in" class="auth_mail} ; ^{ram.cdri@gmail.com" class="auth_mail} ; Chada Narsimha Reddy^a ; Geeta Sai Mani^a ; Jeevak Sopanrao Kapure^a ; Praveen Reddy Adiyala^a ; Jagadeesh Babu Nanubolu^b ; Kiran Kumar Singarapu^c ; Ahmed Kamal^a ; ^{ahmedkamal@iict.res.in" class="auth_mail}
• 关键词：Spiro compounds ; Ethyl diazoacetate ; Cyclopropanation ; Stereoselective synthesis ; Indolin-2-one
• 刊名：Tetrahedron
• 出版年：12 August 2014
• 年：2014
• 卷：70
• 期：32
• 页码：4709-4717
• 全文大小：708 K

文摘

Substituted 3-methyleneindolin-2-ones were efficiently cyclopropanated with ethyl diazoacetate to yield spiro[cyclopropane-1,3′-indolin]-2′-ones in a catalyst-free and highly diastereoselective reaction in a mixture of ethanol–acetonitrile (1:1 v/v) as solvent.