Evidence that cytochrome b5 acts as a redox donor in CYP17A1 mediated androgen synthesis
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- 作者：Ruchia Duggala ; Yilin Liub ; Michael C. Gregorya ; Ilia G. Denisova ; James R. Kincaidb ; Stephen G. Sligara ; c ; s-sligar@illinois.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：CYP17A1 ; Cytochrome b5 ; Redox donor ; Androgen synthesis ; Nanodiscs
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：19 August 2016
- 年：2016
- 卷：477
- 期：2
- 页码：202-208
- 全文大小：1155 K
文摘
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Cyt b5 role in human CYP17A1 mediated androgen synthesis was probed in Nanodiscs.
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Native cyt b5 enhances androgen synthesis by CYP17A1.
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Redox inactive Mn cyt b5 does not enhance androgen synthesis by CYP17A1.
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Interactions with Cyt b5 perturb Fe
S and heme Raman modes of CYP17A1.- •
Cyt b5 acts as a redox donor for CYP17A1 mediated androgen synthesis.