In vitro screening of 2-(1H-imidazol-1-yl)-1-phenylethanol derivatives as antiprotozoal agents and docking studies on Trypanosoma cruzi CYP51
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- 作者：Daniela De Vitaa ; daniela.devita@uniroma1.it" class="auth_mail" title="E-mail the corresponding author ; Francesca Moracac ; Claudio Zamperinic ; Fabiana Pandolfia ; Roberto Di Santoa ; b ; An Matheeussend ; Louis Maesd ; Silvano Tortorellaa ; Luigi Scipionea
- 关键词：Trypanosoma cruzi ; Azoles ; CYP51
- 刊名：European Journal of Medicinal Chemistry
- 出版年：2016
- 出版时间：4 May 2016
- 年：2016
- 卷：113
- 期：Complete
- 页码：28-33
- 全文大小：1077 K
文摘
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A number of azoles with selective activity against Trypanosoma cruzi were identified.
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The most active compound possesses 40 nM IC50.
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The biological activity of pure enantiomers was evaluated.
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Molecular docking on T. cruzi CYP51 was assessed to rationalize biological data.