IV glycine and oral d-cycloserine effects on plasma and CSF amino acids in healthy humans

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• 作者：D’ ; Souza ; Deepak Cyril ; Gil ; Roberto ; Cassello ; Karyn ; Morrissey ; Kristen ; Abi-Saab ; Danielle ; et. al.
• 关键词：Glycine ; d-cycloserine ; strychnine-insensitive ; NMDA receptors ; cerebrospinal fluid ; amino acids
• 刊名：Biological Psychiatry
• 出版年：2000
• 出版时间：March 1, 2000
• 年：2000
• 卷：47
• 期：5
• 页码：450-462
• 全文大小：189 K

文摘

Background: The amino acid glycine, modulates neurotransmission via actions at GLY-A receptor and GLY-B receptor. The latter are coagonist sites associated with N-Methyl-d-Aspartate (NMDA) glutamate receptors. The central bioavailability of peripherally administered glycine has not been adequately characterized in humans.