DNA methylation in cystathionine-γ-lyase (CSE) gene promoter induced by ox-LDL in macrophages and in apoE knockout mice
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- 作者：Hua-Ping Dua ; 1 ; Jiaojiao Lia ; 1 ; Shou-Jiang Youa ; Ya-Li Wanga ; Fen Wanga ; Yong-Jun Caoa ; Li-Fang Hua ; b ; hulifang@suda.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Chun-Feng Liua ; b ; c
- 关键词：Atherosclerosis ; Cystathionine γ-lyase ; DNA methylation ; Hydrogen sulfide ; Macrophage ; ox-LDL
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：15 January 2016
- 年：2016
- 卷：469
- 期：3
- 页码：776-782
- 全文大小：1442 K
文摘
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Plasma H2S in apoE−/− mice was lower than that in control mice.
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CSE mRNA and H2S generation in the peritoneal macrophages of apoE−/− mice decreased.
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DNMT expression and activity in the macrophages were enhanced.
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DNA methylation of cse gene promoter was increased in the macrophages.
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Inhibition of DNMT attenuated ox-LDL-induced cse mRNA decrease in macrophages.