Angelica sinensis polysaccharide attenuates concanavalin A-induced liver injury in mice
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- 作者：Kaiping Wanga ; Zhizhen Songa ; Hongjing Wanga ; Qiang Lib ; Zheng Cuib ; Yu Zhangb ; zhangwkp@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：ASP ; Angelica sinensis polysaccharide ; ConA ; concanavalin A ; HPGPC ; high performance gel permeation chromatography ; TNF-α ; tumor necrosis factor alpha ; SOD ; superoxide dismutase ; MDA ; malondialdehyde ; ROS ; reactive oxygen species ; CASPASE ; cysteine-aspartic acid specific protease ; JNK ; c-Jun N-terminal kinase
- 刊名：International Immunopharmacology
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：31
- 期：Complete
- 页码：140-148
- 全文大小：1566 K
文摘
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Angelica sinensis polysaccharide (ASP) inhibited ConA-induced lymphoproliferative response.
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ASP pretreatment decreased proinflammatory cytokines and alleviated oxidative stress after intravenous ConA administration in mice.
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ASP attenuated Caspase-3-dependent apoptosis by Caspase-8 and JNK-mediated pathway in ConA-induced liver injury in mice.
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ASP inhibited IL-6/STAT3 and NF-κB signaling pathways in ConA-induced liver injury in mice.