Cell surface cathepsin G activity differs between human natural killer cell subsets
详细信息 查看全文
- 作者：Adriane Penczeka ; Marcin Sienczykb ; Christian Rainer Wirtza ; Timo Burstera ; timo.burster@uni-ulm.de" class="auth_mail" title="E-mail the corresponding author
- 关键词：Caspase ; cysteine-aspartic protease ; Cat ; cathepsin ; KIR ; killer-cell Ig-like receptor ; MARS116 ; Marcin Sienczyk 116 ; Bt-LC-Suc-Val-Pro-PheP(OPh)2 ; MFI ; median fluorescence intensity ; MHC ; major histocompatibility complex ; MMP ; matrix metalloproteinase ; NE ; neutrophil elastase ; NK cells ; natural killer cells ; PBMCs ; peripheral blood mononuclear cells ; PR3 ; proteinase 3 ; SDF-1 ; chemokine stromal cell-derived factor 1
- 刊名：Immunology Letters
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：179
- 期：Complete
- 页码：80-84
- 全文大小：1477 K
文摘
- •
Natural killer (NK) cells are involved in diverse defense mechanisms.
- •
Cell surface level of cathepsin G differs between NK cell subsets.
- •
CatG was determined on the protein- (CatG-specific antibody) and activity level (activity-based probe MARS116) by using flow cytometry.
- •
MARS116 is a novel reporter for cell surface CatG activity and can be used to differentiate between distinct NK cell subsets.