Identification of Aadnr1, a novel gene related to innate immunity and apoptosis in Aedes albopictus
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- 作者：Xiaomei Li ; Kun Meng ; Jialu Qiao ; Hao Liu ; Chunyan Zhong ; Qingzhen Liu ; qzhliu@whu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：AacecA ; Aedes albopictus cecropin A ; AaDnr1 (or Aadnr1) ; Aedes albopictus Dnr1 (or dnr1) ; Aas7 ; Aedes albopictus ribosomal protein s7 ; Act D ; Actinomycin D ; AeDnr1 (or Aednr1) ; Aedes aegypti Dnr1 (or dnr1) ; AMP ; antimicrobial peptide ; bp ; base pair (s) ; caspase (s) ; cysteine-aspartic protease (s) ; cDNA ; DNA complementary to RNA ; CHIKV ; Chikungunya virus ; DAP ; diaminopimelic acid ; DENV ; Dengue virus ; DNase ; deoxyribonuclease ; Dnr1 (dnr1) ; Defense repressor 1 ; Dredd ; death-related ced-3/Nedd2-like
- 刊名：Gene
- 出版年：2016
- 出版时间：1 August 2016
- 年：2016
- 卷：587
- 期：1
- 页码：18-26
- 全文大小：1321 K
文摘
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Aadnr1, an ortholog of Drosophila dnr1 from Aedes albopictus C6/36 cells was identified.
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Aadnr1 was expressed during all the developmental and adult stages.
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Transcriptional level of Aadnr1 was decreased under apoptotic and immune stimuli.
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Silence of AaDnr1 enhanced Act D-induced caspase activity.
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RING domain destabilized AaDnr1 protein.