A simple fluorescent probe for sensing cysteine over homocysteine and glutathione based on PET

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• 作者：Wenlong Fan^a ; Ximing Huang^a ; Xiaomin Shi^a ; Zhuo Wang^b ; Zhengliang Lu^a ; ^{zhengliang.lu@yahoo.com} ; ^{chm_luzl@ujn.edu.cn} ; Chunhua Fan^a ; Qibing Bo^a
• 关键词：Fluorescence ; Probe ; Cysteine ; Selectivity ; Bioimaging
• 刊名：Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy
• 出版年：2017
• 出版时间：15 February 2017
• 年：2017
• 卷：173
• 期：Complete
• 页码：918-923
• 全文大小：920 K
• 卷排序：173

文摘

A simple fluorescent probe for specific detection of cysteine based on PET was developed. The acrylate and BODIPY moieties in the probe act as a reaction site and reporter group, respectively. The synergistic effect of the substituent groups endows the probe very strong green fluorescence at 525 nm (λex = 500 nm). The probe is successfully applied for sensing and imaging cysteine in vitro or in vivo cells with low cytotoxicity.