Lipoamino acid-based micelles as promising delivery vehicles for monomeric amphotericin B
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- 作者：Clá ; udia Serafima ; Inê ; s Ferreiraa ; Patrí ; cia Rijoa ; b ; Lí ; dia Pinheiroa ; Cé ; lia Faustinoa ; cfaustino@ff.ulisboa.pt" class="auth_mail" title="E-mail the corresponding author ; Antó ; nio Caladoa ; Luis Garcia-Rioc
- 关键词：Amphotericin B (PubChem CID ; 5280965) ; Sodium cholate (PubChem CID ; 23668194) ; Sodium deoxycholate (PubChem CID ; 23668196) ; l-Cystine (PubChem CID ; 67678)
- 刊名：International Journal of Pharmaceutics
- 出版年：2016
- 出版时间：30 January 2016
- 年：2016
- 卷：497
- 期：1-2
- 页码：23-35
- 全文大小：935 K
文摘
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Lipoamino acid (LAA) derived from cysteine was able to solubilize amphotericin B (AmB).
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LAA micelles and micellar equimolar mixtures with bile salts sodium cholate (NaC) and sodium deoxycholate (NaDC) were better solubilising agents towards AmB than pure bile salt micelles.
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LAA-containing micellar systems solubilised AmB in its monomeric and less toxic form.
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AmB solubilised in LAA-based micelles had in vitro antifungal activity against Candida albicans comparable to commercial formulation Fungizone.