Ca2+ signalling in human proximal tubular epithelial cells deficient for cystinosin
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- 作者：Ekaterina A. Ivanovaa ; Mohamed A. Elmonema ; b ; mohamed.ibrahim@kuleuven.be" class="auth_mail" title="E-mail the corresponding author ; Inge Bongaertsa ; Tomas Luytenc ; Ludwig Missiaenc ; Lambertus P. van den Heuvela ; d ; Elena N. Levtchenkoa ; Geert Bultynckc
- 关键词：Lysosomal storage disorders ; Nephropathic cystinosis ; Calcium homeostasis
- 刊名：Cell Calcium
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：60
- 期：4
- 页码：282-287
- 全文大小：981 K
文摘
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We investigated cellular Ca+2 signalling for the first time in nephropathic cystinosis.
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ATP-induced Ca2+ release was slightly potentiated in cystinotic proximal tubular epithelial cells (PTECs).
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The content of acidic Ca2+ stores in cystinotic PTECs were similar to wild-type PTECs.
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IP3-induced Ca2+ release and ITPR3 gene expression were unaffected in cystinotic PTECs.