Improving antiproliferative effect of the anticancer drug cytarabine on human promyelocytic leukemia cells by coating on Fe3O4@SiO2 nanoparticles
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- 作者：Nahid Shahabadia ; b ; nahidshahabadi@yahoo.com" class="auth_mail" title="E-mail the corresponding author ; Monireh Falsafia ; Kamran Mansourib ; c
- 关键词：Magnetic nanoparticles ; Coprecipitation reaction ; Cytarabine ; Antiproliferative effect ; Human promyelocytic leukemia cell line
- 刊名：Colloids and Surfaces B: Biointerfaces
- 出版年：2016
- 出版时间：1 May 2016
- 年：2016
- 卷：141
- 期：Complete
- 页码：213-222
- 全文大小：2006 K
文摘
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Fe3O4@SiO2-cytarabine magnetic nanoparticles (MNPs) were prepared for the targeted cancer therapy.
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The characterization results of TEM and XRD showed that the average diameters of Fe3O4@SiO2-cytarabine MNPs were about 23 nm.
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The results of cytotoxicity evaluation showed that nanoparticles have greater effect on the cellular in vitro cytotoxicity than cytarabine.
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The results for DNA binding illustrate that DNA aggregate on the Fe3O4@SiO2-cytarabine MNPs via groove binding.