Simultaneous determination of clofarabine and cytarabine in human plasma by LC-MS/MS
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- 作者：Božena Bü ; ttnera ; bozena.buettner@uniklinikum-dresden.de" class="auth_mail" title="E-mail the corresponding author ; Reinhard Oertelb ; Johannes Scheteligc ; d ; Jan Moritz Middekec ; Martin Bornhä ; userc ; Andreas Seelinge ; Holger Knotha
- 关键词：AML ; acute myeloid leukemia ; ALL ; acute lymphoid leukemia ; CFB ; clofarabine ; CLARA ; chemotherapy regimen with clofarabine 40 ; mg/m2 and cytarabine 1000 ; mg/m2 ; CTB ; cytarabine ; ESI ; electrospray ionisation ; HSCT ; hematopoietic stem cell transplantation ; IS ; internal standard ; LLOQ ; lower limit of quantification ; RR ; relative recovery ; THU ; tetrahydrouridine ; QC sample ; quality control sample
- 刊名：Journal of Pharmaceutical and Biomedical Analysis
- 出版年：2016
- 出版时间：5 June 2016
- 年：2016
- 卷：125
- 期：Complete
- 页码：286-291
- 全文大小：512 K
文摘
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New LC–MS/MS method for simultaneous determination of both clofarabine and cytarabine in human plasma with a good selectivity, accuracy and precision.
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Wide calibration ranges: 8–1000 ng/ml for clofarabine and 20–2500 ng/ml for cytarabine.
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The simple sample preparation and short time of analysis allowed for a high sample throughput.
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Successfully applied to a pharmacokinetic investigation within a hematological trial in adult patients with acute myeloid leukemia.