Mechanisms underlying effect of the mycotoxin cytochalasin B on induction of cytotoxicity, modulation of cell cycle, Ca2+ homeostasis and ROS production in human breast cells
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- 作者：Hong-Tai Changa ; 1 ; Chiang-Ting Choub ; c ; 1 ; I.-Shu Chena ; Chia-Cheng Yua ; Ti Lud ; Shu-Shong Hsua ; Pochuen Shiehe ; Chung-Ren Janf ; Wei-Zhe Liangf ; lianggoole67@gmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Apoptosis ; Ca2+ ; Cell cycle ; Cytochalasin B ; Human breast cells ; ROS
- 刊名：Toxicology
- 出版年：2016
- 出版时间：31 August 2016
- 年：2016
- 卷：370
- 期：Complete
- 页码：1-19
- 全文大小：4274 K
文摘
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Molecular effects of the mycotoxin cytochalasin B were explored in human breast cells.
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In ZR-75-1 cells, cytochalasin B induced G2/M phase arrest that involved p53, p27, p21, cyclin B1 and CDK1 regulation.
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In ZR-75-1 cells, cytochalasin B activated Ca2+-associated mitochondrial apoptotic pathways that involved ROS production.