Sulforaphane (SFN) activated Nrf2 in BV2 cells and increased antioxidant genes.
SFN reduced proinflammatory cytokines in LPS-stimulated BV2 microglia.
SFN increased expression of antioxidant genes in adult and aged microglia.
SFN reduced LPS-induced proinflammatory cytokines in adult and aged microglia.
SFN is a potential therapeutic supplement for aging-related neuroinflammation.