5-Fluorouracil chemotherapy upregulates cytokines and alters hippocampal dendritic complexity in aged mice
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- 作者：Thomas R. Grovesa ; b ; c ; Ryan Farrisd ; Julie E. Andersona ; b ; Tyler C. Alexandera ; b ; Frederico Kiffera ; b ; Gwendolyn Cartera ; b ; Jing Wanga ; b ; Marjan Boermaa ; b ; Antiñ ; o R. Allena ; b ; c ; AAllen@uams.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：5-Fluorouracil ; Hippocampus ; Dendritic spines ; Cytokines ; Chemokines
- 刊名：Behavioural Brain Research
- 出版年：2017
- 出版时间：1 January 2017
- 年：2017
- 卷：316
- 期：Complete
- 页码：215-224
- 全文大小：1974 K
文摘
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5-Fu significantly compromised the dendritic architecture.
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5-Fu decreased spine density and modulated spine morphology throughout Hippocampus.
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5-Fu upregulated pro-inflammatory and anti-inflammatory cytokines.