Among the different types of autophagy, macroautophagy is the best characterized.
The biogenesis of the phagophore or autophagosome is a key step in the process.
Tight regulation of macroautophagy is important for normal cellular function.
Autophagy-related proteins that form the autophagosome constitute the core machinery.
Macroautophagy can be nonselective or selective for specific cargos.