Sensing Membrane Curvature in Macroautophagy

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• 作者：Nathan Nguyen^&dagger ; ; ^{Nathan.nguyen@yale.edu} ; Vladimir Shteyn^&dagger ; ; ^{vladimir.shteyn@yale.edu} ; Thomas J. Melia ; ^{thomas.melia@yale.edu}
• 关键词：EM ; electron microscopy ; IM ; isolation membrane ; ER ; endoplasmic reticulum ; Atg ; autophagy-related ; BAR ; Bin/amphiphysin/Rvs ; Cvt ; cytoplasm-to-vacuole targeting ; RE ; recycling endosome ; BATS ; Barkor/Atg14(L) autophagosome targeting sequence ; GUV ; giant unilamellar vesicle ; GFP ; green fluorescent protein
• 刊名：Journal of Molecular Biology
• 出版年：2017
• 出版时间：17 February 2017
• 年：2017
• 卷：429
• 期：4
• 页码：457-472
• 全文大小：826 K
• 卷排序：429

文摘

Autophagosome biogenesis involves significant structural remodeling of cellular membranes. Proteins target these unique morphologies via curvature-sensing motifs. Each of the major autophagy complexes utilizes one or more curvature-sensitive proteins.