Life after hyperthermic intraperitoneal chemotherapy; measuring quality of life and performance status after cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy

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• 作者：Jennifer Ford ; M.D.^a ; Michael Hanna ; B.S.^b ; Anna Boston ; A.N.P.B.C.^c ; Richard Berri ; M.D.^c ; ^{richard.berri@stjohn.org" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Cytoreductive surgery ; Hyperthermic intraperitoneal chemoptherapy ; Quality of life ; Performance status
• 刊名：The American Journal of Surgery
• 出版年：2016
• 出版时间：March 2016
• 年：2016
• 卷：211
• 期：3
• 页码：546-550
• 全文大小：148 K

文摘

Patients who undergo cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC) can return to an acceptable performance status (PS) and quality of life 3 months postoperative.

Methods

An HIPEC specific questionnaire was developed based on the validated Functional Assessment of Cancer Therapy Questionnaire. Each patient was contacted and questionnaire completed. An averaged score was calculated and stratified to an Eastern Cooperative Oncology Group PS. A retrospective chart review gathered patient characteristics and correlated to the patient's 3 months postoperative PS.

Results

Between October 2011 and July 2014, 43 patients underwent complete CRS with HIPEC. The most common indications for surgery were colorectal (35%) and appendiceal malignancy (47%). Average scores were: physical well-being 15.4 of 20, social well-being 17.5 of 20, recovery 15 of 20, mental well-being 13.4 of 20, and functional well-being 18.1 of 24. These correlated to an Eastern Cooperative Oncology Group PS of 1, 0, 1, 1, and 1. Patient's age (P = .235), operative length (P = .181), hospital duration (P = .43), complications or peritoneal carcinomatosis index (P = .815) demonstrated no significance relative to postoperative PS.

Conclusions

Patients can recovery well from CRS with HIPEC. It is possible to return to an acceptable functional status within 3 months postoperative. Age, operative time, length of hospital stay, or peritoneal carcinomatosis index have no prohibitive effects on a long-term recovery.