Localized brain differences in Arc expression between mice showing low vs. high propensity to ethanol sensitization
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- 作者：Christina N. Nonaa ; b ; Marcus Lamb ; José ; N. Nobregaa ; b ; c ; d ; jose.nobrega@camh.ca" class="auth_mail" title="E-mail the corresponding author
- 关键词：Alcohol ; Behavioral sensitization ; Immediate early gene ; Activity-regulated cytoskeleton-associated protein (Arc) ; DBA/2 mice ; Locomotor activity ; Central amygdala
- 刊名：Pharmacology Biochemistry and Behavior
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：142
- 期：Complete
- 页码：15-22
- 全文大小：938 K
文摘
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DBA/2 mice differ in their locomotor response to repeated ethanol (EtOH).
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Regional brain activity patterns were compared at two time points in HS and LS mice.
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Arc levels decreased throughout the brain in HS and LS mice compared to controls.
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After an EtOH challenge, Arc increased in the central amygdala in LS and control mice.
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Central amygdala activation may serve to inhibit the stimulant effects of EtOH.