α-Tocopheryl linolenate solid lipid nanoparticles for the encapsulation, protection, and release of the omega-3 polyunsaturated fatty acid: in vitro anti-melanoma activity evaluation
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- 作者：Roberta Cassano ; Silvia Mellace ; Mariangela Marrelli ; Filomena Conforti ; Sonia Trombino ; sonia.trombino@unical.it
- 关键词：Omega-3 ; α-Tocopheryl linolenate ; Solid lipid nanoparticles ; Antioxidant ; Melanoma ; Cytotoxic
- 刊名：Colloids and Surfaces B: Biointerfaces
- 出版年：2017
- 出版时间：1 March 2017
- 年：2017
- 卷：151
- 期：Complete
- 页码：128-133
- 全文大小：983 K
- 卷排序：151
文摘
SLNs based on α-tocopheryl linolenate were prepared and characterized. α-tocopheryl linolenate and the obtained SLNs show an excellent antioxidant activity. SLNs deliver and the protect unstable molecules, such as α-linolenic acid, from degradation. SLNs are more effective than both α-linolenic acid α-tocopherol in inhibiting human melanoma cell viability in vitro. SLNs could be good candidates for further in vivo studies to develop potential agents in the treatment of melanoma.