Targeting tumor microenvironment with PEG-based amphiphilic nanoparticles to overcome chemoresistance

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• 作者：Shizhu Chen ; MSc^a ; ¹ ; Keni Yang ; MSc^b ; ¹ ; Ruslan G. Tuguntaev ; MSc^b ; Anbu Mozhi ; MSc^b ; Jinchao Zhang ; PhD^a ; ^{jczhang6970@163.com" class="auth_mail" title="E-mail the corresponding author} ; Paul C. Wang ; PhD^c ; ^d ; Xing-Jie Liang ; PhD^b ; ^{liangxj@nanoctr.cn" class="auth_mail" title="E-mail the corresponding author}
• 关键词：ABCs ; ATP-binding cassette superfamily ; AUC ; area under the curve ; BBB ; blood brain barrier ; BCRP ; breast cancer resistance protein ; CMC ; critical micellar concentration ; CT ; computed tomography ; CUR ; curcumin ; DOX ; doxorubicin ; DSPE-PEG ; 1 ; 2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)] ; EGF ; epidermal growth factor ; EGFR ; epidermal growth factor receptor ; EPR ; enhanced permeability and retention ; FA ; folic acid ; FDA ; Food and Drug Administration ; IVCLSM ; intravit
• 刊名：Nanomedicine: Nanotechnology, Biology and Medicine
• 出版年：2016
• 出版时间：February 2016
• 年：2016
• 卷：12
• 期：2
• 页码：269-286
• 全文大小：2621 K

文摘

Multidrug resistance is one of the biggest obstacles in the treatment of cancer. Recent research studies highlight that tumor microenvironment plays a predominant role in tumor cell proliferation, metastasis, and drug resistance. Hence, targeting the tumor microenvironment provides a novel strategy for the evolution of cancer nanomedicine. The blooming knowledge about the tumor microenvironment merging with the design of PEG-based amphiphilic nanoparticles can provide an effective and promising platform to address the multidrug resistant tumor cells. This review describes the characteristic features of tumor microenvironment and their targeting mechanisms with the aid of PEG-based amphiphilic nanoparticles for the development of newer drug delivery systems to overcome multidrug resistance in cancer cells.

From the Clinical Editor

Cancer is a leading cause of death worldwide. Many cancers develop multidrug resistance towards chemotherapeutic agents with time and strategies are urgently needed to combat against this. In this review article, the authors discuss the current capabilities of using nanomedicine to target the tumor microenvironments, which would provide new insight to the development of novel delivery systems for the future.