A thiol fluorescent probe reveals the intricate modulation of cysteine's reactivity by Cu(II)
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- 作者：Huiru Lua ; b ; Huatang Zhangc ; Jun Chena ; Jinchao Zhangb ; jczhang6970@163.com" class="auth_mail" title="E-mail the corresponding author ; Ruochuan Liuc ; Hongyan Sunc ; hongysun@cityu.edu.hk" class="auth_mail" title="E-mail the corresponding author ; Yuliang Zhaoa ; Zhifang Chaia ; Yi Hua ; huyi@ihep.ac.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Copper ; Cysteine ; Fluorescent probe ; Ellman's reagent ; Cell imaging
- 刊名：Talanta
- 出版年：2016
- 出版时间：1 January 2016
- 年：2016
- 卷：146
- 期：Complete
- 页码：477-482
- 全文大小：2002 K
文摘
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We reported that a fluorescent probe could detect Cu(II) at subnanomolar concentrations.
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Cu(II) is a specific and potent inhibitor of cysteine.
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Cu(II) can differentially modulate the reactivity of cysteinyl thiol.
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Cell imaging experiments confirmed the inhibitory effects of Cu(II) on Cys's reactivity.