Exosome release following activation of the dendritic cell immunoreceptor: A potential role in HIV-1 pathogenesis
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- 作者：Claude M. Mfunyi1 ; Myriam Vaillancourt1 ; Julien Vitry ; Thy-René ; Nsimba Batomene ; Alma Posvandzic ; Alexandra A. Lambert ; Caroline Gilbert ; caroline.gilbert@crchudequebec.ulaval.ca" class="auth_mail" title="E-mail the corresponding author
- 关键词：DCIR ; dendritic cell immunoreceptor ; DC-SIGN ; dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin ; AChE ; acetylcholinesterase ; BK ; Bradykinin ; iMDDC ; immature monocyte-derived dendritic cell ; ITIM ; immunoreceptor tyrosine-based inhibition motif ; DCIR inhibitor ; 1-methyl-4-[4-methyl p-NNO-azoxy] benzene ; MTT ; thiazolyl blue tetrazolium bromide ; CD4TL ; CD4 T lymphocyte
- 刊名：Virology
- 出版年：2015
- 出版时间：October 2015
- 年：2015
- 卷：484
- 期：Complete
- 页码：103-112
- 全文大小：1124 K
文摘
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DCIR plays a signaling role in the release of exosomes (AChE+ vesicles).
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Signal transduction via the ITIM motif is involved in this release.
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Proteins contained in EVs derived from HIV-1-infected cells are enriched in DAP-3.
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EVs may play a role in HIV-1 pathogenesis by inducing apoptosis in CD4TL.
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EVs may increase neutrophil lifespan.