Adiposity, Fat Patterning, and the Metabolic Syndrome among Diverse Youth: The EPOCH Study

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• 作者：Marybeth Maligie ; MPH¹ ; Tessa Crume ; PhD¹ ; Ann Scherzinger ; PhD² ; Elizabeth Stamm ; MD² ; Dana Dabelea ; MD ; PhD¹ ; ^{Dana.Dabelea@ucdenver.edu}
• 关键词：BMI ; Body mass index ; EPOCH ; Exploring perinatal outcomes among children ; HDLc ; High density lipoprotein cholesterol ; IMCL ; Intramyocellular lipid ; NHANES ; National Health and Nutrition Examination Survey ; SAT ; Subcutaneous adipose tissue ; STR ; Subscapula
• 刊名：The Journal of Pediatrics
• 出版年：2012
• 出版时间：November, 2012
• 年：2012
• 卷：161
• 期：5
• 页码：875-880
• 全文大小：310 K

文摘

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Objectives

To assess fat distribution, prevalence of obesity, and the metabolic syndrome among diverse 6-13-year-old Colorado youth to better understand racial/ethnic influences on adiposity and metabolic syndrome.

Study design

We measured body mass index, subscapular-to-triceps skinfold ratio, waist circumference, dietary fat, and physical activity in 422 youth (47 % non-Hispanic White, 44 % Hispanic, and 9 % African-American). Visceral adipose tissue, subcutaneous adipose tissue, and intramyocellular lipid were measured with magnetic resonance techniques. Multiple-linear regression was used to assess associations between race/ethnicity and adiposity patterns.

Results

Hispanic and African-American youth had a higher prevalence of obesity and metabolic syndrome compared with non-Hispanic White youth. Both groups displayed a more centralized fat distribution and larger volumes of subcutaneous tissue, compared with non-Hispanic White youth. After controlling for body mass index, these differences were attenuated, and for a given body size, African-American youth showed significantly lower visceral adipose tissue than non-Hispanic White youth. However, both Hispanic and African-American youth showed higher intermyocellular lipid in skeletal muscle compared with non-Hispanic Whites, independent of body size.

Conclusions

Racial/ethnic minorities experience higher overall adiposity, and may also have an increased risk for early development of metabolic syndrome relative to non-Hispanic White youth, beyond their increased obesity risk.