文摘
Ts65Dn mice demonstrated impaired learning and attention, which were ameliorated by maternal choline supplementation (MCS). MCS improved attention in both Ts65Dn and 2N offspring, but did not alter morphology of cholinergic neurons in the NBM/SI. Ts65Dn mice exhibited an increased number of BFCNs in the NMB/SI and a decreased number of BFCNs in the MSN. The soma volume of BFCNs in both basal forebrain regions was significantly larger in Ts65Dn mice, relative to 2N controls. Attentional performance was inversely associated with BFCN volume, and positively associated with BFCN density.