Reproducibility of Brachial Vascular Changes with Alterations in End-Tidal Carbon Dioxide

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• 作者：Justin R. Geijer^&lowast ; ; Nicholas G. Evanoff^&dagger ; ; Aaron S. Kelly^&Dagger ; ; ^§ ; ; Michael A. Chernin^&dagger ; ; Matthew G. Stoltman^&dagger ; ; Donald R. Dengel^&dagger ; ; ^&Dagger ; ; ^{denge001@umn.edu" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Hypercapnia ; Ultrasound ; Vasodilation
• 刊名：Ultrasound in Medicine & Biology
• 出版年：2016
• 出版时间：July 2016
• 年：2016
• 卷：42
• 期：7
• 页码：1450-1456
• 全文大小：393 K

文摘

The purpose of this study was to examine the reproducibility of the peripheral vascular response to hypercapnia. Healthy college-aged men (n = 7) and women (n = 10) underwent an iso-oxic 10-mm Hg increase in P_etCO₂ for 12 min. Brachial artery diameter changes were measured using ultrasound imaging. Two tests were completed on day 1 with 15 min of rest between tests. Tests were repeated on day 2. Paired t-tests, Bland–Altman plots and intra-class correlations (ICCs) determined reproducibility. There were no significant differences in peak dilation within day (5.33 ± 3.73% vs. 4.52 ± 2.49%, p = 0.378). The within-day ICC was poor (0.213). Within-day time-to-peak dilation did not significantly differ (660.0 ± 231.8 s vs. 602.7 ± 259.9 s, p = 0.379), and the ICC was fair (0.416, p = 0.113). Between-day peak dilation did not significantly differ (5.24 ± 3.84% vs. 4.71 ± 3.17%, p = 0.123), and the ICC was fair (0.419). Hypercapnia-induced brachial artery dilation is similar within day and between days. The ICC for peak dilation suggests the methodology is not reproducible.