Counter-regulation of the AP-1 monomers pATF2 and Fos: Molecular readjustment of brainstem neurons in hearing and deaf adult rats after electrical intracochlear stimulation
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- 作者：A.-K. Rauch&dagger ; ; ann-kathrin.rauch@uniklinik-freiburg.de" class="auth_mail" title="E-mail the corresponding author ; N. Rosskothen-Kuhl ; &dagger ; ; nicole.rosskothen@uniklinik-freiburg.de" class="auth_mail" title="E-mail the corresponding author ; R.-B. Illing robert.illing@uniklinik-freiburg.de" class="auth_mail" title="E-mail the corresponding author
- 关键词：ABR ; auditory brainstem response ; ANOVA ; analysis of variance ; AP-1 ; activator protein-1 ; ATF2 ; activating transcription factor-2 ; AVCN ; anteroventral cochlear nucleus ; AVCNi ; AVCN ipsilateral to stimulation ; c ; contralateral ; CI ; cochlear implant ; CIC ; central inferior colliculus ; CICc ; CIC contralateral to stimulation ; c-Jun ; product of the immediate-early gene c-jun ; Co ; control ; CREB ; cAMP response element-binding protein ; DAB ; 3 ; 3&prime ; -diaminobenzidine tetrahydrochloride ; dB ; decibel ; EAB
- 刊名：Neuroscience
- 出版年：2016
- 出版时间：28 January 2016
- 年：2016
- 卷：313
- 期：Complete
- 页码：184-198
- 全文大小：3376 K
文摘
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Fos and pATF2 are competing monomers for the dimeric AP-1 transcription factor.
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Auditory nerve stimulation counter-regulates Fos and pATF2 expression in hearing and deaf rats.
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Increase of stimulation-dependent Fos expression is matched by decrease of pATF2 in AVCN and LSO.
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Fos and pATF2 favor different plasticity-related transcription cascades.