Context-dependent efficacy of a counter-conditioning strategy with atypical neuroleptic drugs in mice previously sensitized to cocaine

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• 作者：AJ Oliveira-Lima^a ; ¹ ; ^{alelimabiologo@hotmail.com} ; EAV Marinho^a ; ¹ ; R Santos-Baldaia^b ; AW Hollais^b ; MA Baldaia^d ; F Talhati^d ; LT Ribeiro^d ; R Wuo-Silva^b ; LF Berro^c ; ^{berro.lf@gmail.com} ; R Frussa-Filho^c ; ^d ; ^&dagger ; ; ^&dagger ;
• 关键词：Aripiprazole ; Behavioral sensitization ; Cocaine ; Counter-conditioning ; Mice ; Ziprasidone
• 刊名：Progress in Neuro-Psychopharmacology and Biological Psychiatry
• 出版年：2017
• 出版时间：6 February 2017
• 年：2017
• 卷：73
• 期：Complete
• 页码：49-55
• 全文大小：598 K
• 卷排序：73

文摘

Ziprasidone decreased spontaneous locomotion and conditioned locomotion to cocaine. Aripiprazole decreased the expression of conditioned hyperlocomotion to cocaine. Ziprasidone/aripiprazole decreased cocaine sensitization in a context-dependent way. Aripiprazole decreased acute cocaine hyperlocomotion in a context-dependent manner. Aripiprazole/ziprasidone treatments were not effective when given in the home-cage.