The amelioration of composite tissue allograft rejection by TIM-3-modified dendritic cell: Regulation of the balance of regulatory and effector T cells
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- 作者：Yaojun Wang1 ; Zhao Zheng1 ; Xiongxiang Zhu ; Juntao Han ; Maolong Dong ; Ke Tao ; Hongtao Wang ; Yunchuan Wang ; Dahai Hu ; dahaihuxian@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：CTA ; composite tissue allotransplantation ; TIM-3 ; T cell Ig domain and mucin domain 3 ; Th1 ; T helper 1 ; mDCs ; mature dendritic cells ; LSBF ; a laser speckle blood flow imager ; Tregs ; regulatory T cells ; Teffs ; effector T cells ; RBC ; red blood cell ; GM-CSF ; granulocyte-macrophage colony-stimulating factor ; IL-2 ; interleukin-2 ; IL-4 ; interleukin-4 ; IL-10 ; interleukin-10 ; LPS ; lipopolysaccharide ; IFN-γ ; interferon-γ ; FOXP3+ ; forkhead box P3+ ; ABTC ; 22'-azino-di(3-ethylbenzthiazolin-sulfonate) ; PBMCs
- 刊名：Immunology Letters
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：169
- 期：Complete
- 页码：15-22
- 全文大小：2346 K
文摘
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TIM-3 can mitigate allograft rejection and enhance immune tolerance in CTA.
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TIM-3 can induce lymphocyte hyporesponsiveness in CTA.
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TIM-3 can regulate the balance of regulatory and effector T cells in CTA.