Safety of docosahexaenoic acid (DHA) administered as DHA ethyl ester in a 9-month toxicity study in dogs
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- 作者：Irina Dahmsa ; Irina.dahms@dsm.com" class="auth_mail" title="E-mail the corresponding author ; Paul Beilsteinb ; Kimberly Bonnettec ; Norman Salem Jr.a
- 关键词：Docosahexaenoic acid ; DHA ethyl ester ; Dogs ; Safety ; Algal oil
- 刊名：Food and Chemical Toxicology
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：92
- 期：Complete
- 页码：50-57
- 全文大小：354 K
文摘
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Concentrated DHA Ethyl Ester (DHA-EE) was administered to beagle dogs at dose levels 150, 1000 and 2000 mg/kg bw/day by oral gavage in this 9-month study.
DHA-EE was well tolerated; clinical findings of occasional reddened areas and dry flaky skin were observed at doses ≥1000 mg/kg bw/day in both sexes.
Test article-related changes in hematology parameters were limited to decreases in reticulocyte count in the high-dose males.
DHA-EE administration resulted in dose-related reductions in cholesterol and triglyceride levels in both sexes.
The no-observed-adverse-effect level (NOAEL) of DHA-EE was established at 2000 mg/kg bw/day for both genders.