Kinetics of docosahexaenoic acid ethyl ester accumulation in dog plasma and brain
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- 作者：Irina Dahms ; Irina.dahms@dsm.com" class="auth_mail" title="E-mail the corresponding author ; Eileen Bailey-Hall ; Norman Salem Jr.
- 关键词：Docosahexaenoic acid ; DHA ethyl ester ; Dogs ; Kinetics ; Algal oil ; Brain ; Plasma
- 刊名：Prostaglandins, Leukotrienes and Essential Fatty Acids
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：113
- 期：Complete
- 页码：1-8
- 全文大小：521 K
文摘
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Concentrated DHA Ethyl Ester (DHA-EE) was administered to beagle dogs at doses up to 2000 mg/kg bw/day by oral gavage in this 9-month study.
DHA-EE was well tolerated; occasional reddened areas and dry flaky skin were observed at doses ≥1000 mg/kg bw/day in both sexes.
DHA-EE administration resulted in DHA increases in the brain and plasma.
Plasma dog levels reached a steady state at the dose of 1000 mg/kg bw/day.
To maximize dog brain levels of DHA, 150 mg/kg bw/day is sufficient if DHA is administered chronically.