mTORC1 is a critical mediator of oncogenic Semaphorin3A signaling
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- 作者：Daisuke Yamada ; Kohichi Kawahara ; Takehiko Maeda ; maeda@nupals.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 关键词：Lung cancer ; Semaphorin3A ; mTOR signaling ; Glycolysis
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：5 August 2016
- 年：2016
- 卷：476
- 期：4
- 页码：475-480
- 全文大小：871 K
文摘
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Sema3A knockdown decreased proliferation of Lewis lung carcinoma cells (LLCs).
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Sema3A knockdown decreased mTORC1 levels and glycolytic activity in LLCs.
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Sema3A knockdown sensitized cells to inhibition of oxidative phosphorylation.
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Sema3A promotes shift from oxidative phosphorylation to aerobic glycolysis via mTORC1.