Effects of naringin on learning and memory dysfunction induced by gp120 in rats
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- 作者：Shanshan Qina ; 1 ; Qiang Chena ; 1 ; Hui Wub ; 1 ; Chenglong Liua ; Jing Hub ; Dalei Zhanga ; Changshui Xua ; xuchangshui@ncu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：HAD ; HIV-1 associated dementia ; LV ; lateral ventricle ; MWM ; Morris water maze ; P2X7R ; P2X7 receptor ; HIV ; human immunodeficiency virus ; ADC ; AIDS-dementia complex ; SD ; Sprague-Dawley ; ACSF ; artificial cerebrospinal fluid ; PMSF ; phenylmethanesulfonyl fluoride
- 刊名：Brain Research Bulletin
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：124
- 期：Complete
- 页码：164-171
- 全文大小：1492 K
文摘
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Naringin may have therapeutic effect on dementia rats induced by gp120.
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Naringin inhibited the up-regulation of P2X7 receptor induced by gp120 in rats.
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Naringin may inhibit BzATP-activated current enhanced by gp120.
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P65 involved in the catabatic effect of naringin on gp120-induced cognitive deficit.