Intensive Lifestyle Intervention Improves Cardiometabolic and Exercise Parameters in Metabolically Healthy Obese and Metabolically Unhealthy Obese Individuals

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• 作者：Claudie Dalzill ; BSc^a ; ^b ; ^c ; Anil Nigam ; MD^a ; ^b ; ^c ; Martin Juneau ; MD^a ; ^b ; ^c ; Valé ; rie Guilbeault ; Bsc^a ; Elise Latour ; Bsc^a ; Pascale Mauriè ; ge ; PhD^d ; Mathieu Gayda ; PhD^a ; ^b ; ^c ; ^{mathieu.gayda@icm-mhi.org" class="auth_mail}
• 刊名：Canadian Journal of Cardiology
• 出版年：April, 2014
• 年：2014
• 卷：30
• 期：4
• 页码：434-440
• 全文大小：332 K

文摘

Background

The effects of an intensive lifestyle intervention including Mediterranean diet nutritional counselling and high-intensity interval training (HIIT) on body composition, cardiometabolic, and exercise parameters were studied in metabolically unhealthy obese (NMHO) and metabolically healthy but obese (MHO) subjects.

Methods

Fifty-five MHO (51 卤 8 years; waist circumference, 109 卤 13 cm) and 79 NMHO subjects (54 卤 9 years; waist circumference, 112 卤 13 cm) participated in an intensive lifestyle modification program based on Mediterranean diet nutritional counselling and HIIT 2-3 times per week. Body composition, cardiometabolic, and exercise parameters were measured at baseline and after 9 months.

Results

Initially, MHO patients had a lower blood pressure (BP), fasting glycemia, triglycerides, and a higher high-density lipoprotein cholesterol and peak oxygen uptake (VO₂ peak) (P < 0.05) vs NMHO patients. Body mass (P聽< 0.05), waist circumference (P < 0.0001), total and trunk fat mass (P < 0.001), systolic and diastolic BP (P < 0.001), fasting glucose (P < 0.0001), insulin sensitivity (P < 0.05), VO₂ peak and muscle endurance (P < 0.0001) were similarly improved in both groups after the program. Prevalence of NMHO was reduced by 17.91% (P < 0.01) after the program. Similar improvements in body composition, BP, and exercise parameters were found for MHO and NMHO men and women (P < 0.05). In all patients, improvement of VO₂ peak was negatively correlated with improvements in body composition, systolic blood pressure, and resting heart rate (HR) (R聽=聽鈭?.61 to聽鈭?.24; P < 0.05).

Conclusions

A long-term intensive lifestyle program including Mediterranean diet nutritional counselling and HIIT is an appropriate intervention in MHO and NMHO subjects with similar potential clinical health benefits including an improved body composition, BP, fasting glycemia, insulin sensitivity, VO₂ peak, and muscle endurance.