Insulin-like growth factor-1 may mediate chemotherapy resistance in oral neoplastic epithelial cells

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• 作者：Richard Damerau ; Jonathan Collier ; St. John Crean ; Ken Parkinson
• 关键词：Suction drains ; Drains ; Staples
• 刊名：British Journal of Oral and Maxillofacial Surgery
• 出版年：2007
• 出版时间：October 2007
• 年：2007
• 卷：45
• 期：7
• 页码：e43
• 全文大小：53 K

文摘

We assessed the sensitivity, specificity, and positive and negative predictive value of methylene blue staining in the diagnosis of oral cancer in 58 patients. The sensitivity was 90 % , the specificity 69 % , positive predictive value 74 % , and negative predictive value 87 % . Because of the number of false negatives and false positives we recommend that the diagnosis should always be confirmed by histopathological examination of a biopsy specimen. Methylene blue staining may, however, be useful as a screening tool for oral cancer in large, high-risk groups in a similar way to the more expensive toluidine blue.